Manufacturers failed to adequately warn consumers and the medical community about the risks of liver side effects from Tylenol. Overdose of Acetaminophen causes serious liver injuries like;
- Prolonged Hospitalization due to liver injury
- Liver failure
- Liver transplant and/or being placed on the liver transplant list
- Death due to liver failure
- Active Ingredient: Acetaminophen
- Purpose: Pain reliever/fever reducer
1. Whether the patient was prescribed Tylenol
2. Did the patient have any preexisting liver conditions, allergies or contraindications for the Tylenol drug?
3. Dosage and Intake details
- Critical Review of Drug Prescription Details (325 mg per dosage unit)
- Pharmacy Dispensing Details
- Pharmacy Refill Details (Details of Pharmacy Dispensing Details are taken as Confirmatory)
- Over the counter use
4.Did the patient develop Liver problems after Tylenol intake?
5.Liver problem diagnosis? (liver failure) – Date of diagnoses?
7.Follow-up visits for management
Identify and report cases with the following scenarios:
- No Injuries: Patient took Tylenol but did not develop any liver injury (no injury – case screening)
- No Tylenol Intake
- Injury present even before Tylenol intake: Patient had previous history of liver problems even before taking Tylenol.
Pre-Existing Liver Conditions – Liver cancer, Any form of liver mass, Autoimmune Hepatitis, Alcoholic cirrhosis, Primary Sclerosing Cholangitis, Wilson’s Disease, Budd-Chiari syndrome.
- Effect of Family History and Social Habits: Family history of Liver problems, liver cancer etc.
- Identify and report on missing medical records/pharmacy bills
Apart from identifying critical missing records that are important for the case, provide a detailed outline on what records are needed, why we need them, how did we get a clue that these records are missing and whether the records missing are confirmatory etc. This will also help in following up and retrieving the records.