Proton-pump Inhibitors – Emerging Litigation

Proton-pump inhibitors (PPIs) are a group of drugs whose main action is a pronounced and long-lasting reduction of gastric acid production.  They are the most potent inhibitors of acid secretion available.  This group of drugs followed and largely superseded another group of medications with similar effects, but a different mode of action, called H2-receptor antagonists. Long-term use of PPI medications may increase the risk of the development of chronic kidney disease (CKD).


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