1- Inappropriate antibiotic use can cause this condition which can be fatal.
2- Use of anti-peristaltic Rx such as Imodium or Lomotil is contraindicated in C. diff and can lead to toxic megacolon and death or need for total colectomy.
3- Failure to treat long enough or to discontinue offending antibiotic therapy are also problematic.
4- Failure to timely order the C. diff test or to initiate empiric therapy in a timely manner can lead to poor outcomes.
5- Patients with rapid transit times or an ileus may not be able to absorb enteral therapy and may require enemas with flagyl or vancomycin or intravenous forms of flagyl therapy.